One of the major clinical challenges in these tumors is to identify tumor specific vulnerabilities that can be therapeutically targeted. The lab focuses on understanding the underlying genetic reasons/ mutations that cause such therapeutic vulnerabilities.
In recent years it has become apparent that the genomes of pediatric cancers are more complex than previously anticipated. One phenomenon observed in pediatric cancers is the circularization of DNA.
Our group of physicians and scientists in the Department of Pediatric Hematology and Oncology at the Charité Universitätsmedizin is particularly interested in understanding how refractory neuroblastoma and rhabdomyosarcoma are formed. Our research is focused on the phenomenon of genomic plasticity and its resultant therapeutically targetable vulnerabilities.
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Chamorro González R, et al. Nat Genet. 2023 May;55(5):880-890. doi: 10.1038/s41588-023-01386-y
Helmsauer, K., Valieva, M.E., Ali, S. et al. Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma. Nat Commun 11, 5823 (2020). https://doi.org/10.1038/s41467-020-19452-y
Koche RP, Rodriguez-Fos E, Helmsauer K, et al. Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma. Nat Genet. 2020;52(1):29–34. doi:10.1038/s41588-019-0547-z
Henssen, A. G., Henaff, E., Jiang, E., Eisenberg, A., Carson, J. R., Villasante, C. M., Ray, M., Still, E., Burns, M., Gandara, J., Feschotte, C., Mason, C. E., Kentsis, A.
Henssen, A. G., Althoff, K., Odersky, A., Beckers, A., Koche, R., Speleman, F., Schäfers, S., Bell, E., Nortmeyer, M., Westermann, F., De Preter, K., Florin, A., Heukamp, L., Spruessel, A.,
Henssen, A. G., Jiang E., Zhuang J., Pinello L., Socci N.D., Koche R., Gonen M., Villasante C. M., Armstrong S. A., Bauer D. E., Weng Z., Kentsis A. “Forward genetic
Henssen, A.G., Koche, R. Zhuang J., Jiang E., Reed C., Eisenberg A., Still E., MacArthur I.C., Rodríguez-Fos E., Gonzalez S., Puiggròs M., Blackford A.N., Mason C.E., de Stanchina E., Gönen
Henssen, A.G., Reed, C., Jiang, E., Dorado Garcia, H., von Stebut, J., MacArthur, I.C., Hundsdoerfer, P., Kim, J.H., de Stanchina, E., Kuwahara, Y., Hosoi, H., Ganem, N.J., Dela Cruz, F.,
Han, Y., Lindner, S., Bei, Y., Garcia, H.D., Timme, N., Althoff, K., Odersky, A., Schramm, A., Lissat, A., Künkele, A., Deubzer, H.E., Eggert, A., Schulte, J.H., Henssen A. G. “Synergistic
Schramm, A., Köster, J., Assenov, Y., Althoff, K., Peifer, M., Mahlow, E., Odersky, A., Beisser, D., Ernst, C., Henssen, A.G., Stephan, H., Schröder, C., Heukamp, L., Engesser, A., Kahlert, Y.,
Decaesteker, B., Denecker, G., Van Neste, C., Dolman, E.M., Van Loocke, W., Gartlgruber, M., Nunes, C., De Vloed, F., Depuydt, P., Verboom, K., Rombaut, D., Loontiens, S., De Wyn, J.,
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